Through its own research and development, as well as in-licensing, Neose has established an extensive intellectual property position in the use of enzymes to synthesize complex carbohydrates and remodel recombinant glycoproteins.

Neose has developed proprietary technology to address the need for improved methods of preparing modified peptides and glycopeptides. This includes Neose's proprietary peptide remodeling technology described in detail in several Neose pending patent applications, one of which has published as WO 03/31464. Briefly, this proprietary technology provides several methods for remodeling peptides. In particular, Neose's proprietary technology provides methods for glycosylating peptides, as well as methods for enzyme mediated formation of conjugates between glycosylated and non-glycosylated peptides and agents such as water-soluble polymers, therapeutic moieties, diagnostic moieties, and the like.

Neose's proprietary GlycoAdvance™ technology includes methods and compositions for the in vitro addition and/or deletion of sugars to or from a glycopeptide molecule in a way that produces a peptide molecule having a specific customized or desired glycosylation pattern, preferably including the addition of a modified sugar. The importance of the glycosylation pattern of a peptide is well known in the art, as are the limitations of present in vivo methods for the production of properly glycosylated peptides, particularly when these peptides are produced using recombinant DNA methodology. Neose's proprietary technology enables the production at commercial scale of glycopeptides having a desired glycan structure.

Neose's proprietary GlycoConjugation™ technology includes methods and compositions that provide a peptide conjugate between a water-soluble polymer, a therapeutic moiety, or a diagnostic moiety and a peptide, with the water-soluble polymer or therapeutic/diagnostic moiety covalently attached to the peptide via an intact glycosyl linking group. Neose's proprietary GlycoPEGylation™ technology includes methods and compositions that provide a peptide conjugate between a polyethylene glycol (PEG) polymer and a peptide, with the PEG covalently attached to the peptide via an intact glycosyl linking group.

Core issued U.S. patents

• Three or more enzymes to make complex carbohydrate
• Most important specific pairs of enzymes to make complex carbohydrates
• Specific enzyme gene sequences
• Chemo-enzymatic synthesis of nucleotide sugars
• Glycosylation of recombinant glycoproteins

Pending patent applications

• Current and next generation compositions and methods (GlycoAdvance™, GlycoConjugation™, and GlycoPEGylation™)
• Specific therapeutic and diagnostic applications
• Manufacturing technology developments

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