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Glycosylation of Human IgG Antibodies: Relevance to Therapeutic Applications (PDF)
Roy Jefferis
BioPharm, September 2001

Neose Targets Complex Carbohydrate Products (PDF)
Cort Wrotnowski
Genetic Engineering News, Vol. 21, No. 6, March 15, 2001

Bioprocessing: Glycosylation in Scale-up of Antibody Production (PDF)
K. John Morrow, Jr., Ph.D.
Genetic Engineering News, Vol. 22, No. 12, June 15, 2002

Glycomics: Sugars could be biology's next sweet spot
Erika Jonietz
Technology Review: MIT's Magazine of Innovation, 2001

Glycosylation: A Critical Issue in Protein Development and Manufacturing (PDF)
David Zopf and George Vergis
Pharmaceutical Visions, Spring 2002

GlycoAdvance™ - Glycoprotein Remodeling Overview (PDF)
Victor Sarantschin
Bioprocess News, Vol. 1, Issue 5, September 2001
Reprint courtesy of Bioprocess News

Getting the Glycosylation Right: Implications for the Biotechnology Industry
Nigel Jenkins, Raj B. Parekh, and David C. James
Nature Biotechnology, Vol. 14, August 1996

Therapeutic Biotech Proteins: Product Development Strategies and Challenges from the Preclinical Stage to Commercialization
Andreas Woppmann
New Drugs, Vogel Life Science Media, April 2001

Second Generation Proteins
Jeffrey Dvorin
Start-Up, Vol. 7, No. 2, February 2002

General Glycobiology

Lysosomal enzyme targeting. Kornfeld S. Biochem Soc Trans 1990; 18: 367-74.

Glycobiology: a growing field for drug design. Karlsson KA Trends Pharmacol Sci 1991; 12: 265-72.

Biological Roles of oligosaccharides: all of the theories are correct. Varki A Glycobiology 1993; 3: 97-130.

Functional role of glycosphingolipids in cell recognition and signaling. Hakomori S and Igarashi Y J Biochem (Tokyo) 1995; 118: 1091-103.

Functional roles of gangliosides in bio-signaling. Nagai Y Behav Brain Res 1995; 66: 99-104.

Evolving views of protein glycosylation. Drickamer K and Taylor ME Trends Biochem Sci 1998; 23: 321-4.

Functions of Cell Surface Heparan Sulfate Proteoglycans. Bernfield M, Götte M, Park, PW, Reizes O, Fitzgerald, ML, Lincecum J, and Zako, M Ann Rev Biochem 1999; 68: 729-77.

Evolutionary considerations in relating oligosaccharide diversity to biological function.
Bagneux P and Varki A Glycobiology 1999; 9: 747-55

Neurobiology/Neurology

Significance of ganglioside-mediated glycosignal transduction in neuronal differentiation and development. Nagai Y and Tsuji S Prog Brain Res 1994; 101: 119-26.

Gangliosides: their role in clinical neurology. Nobile-Orazio E, Carpo M, and Scarlato G Drugs 1994; 47: 576-85.

GM1 ganglioside treatment of Parkinson's Disease: an open pilot study of safety and efficacy. Schneider JS, Roeltgen CP, Mancall EL, Chapas-Crilly J, Rothblat DS, and Tatarian GT Neurology 1998; 50: 1631-6.

Glycosylation/Bioengineering

Structure and role of carbohydrate in human erythropoietin. Fukuda M, Sasaki H, and Fukuda MN Adv Exp Med Biol 1989; 271: 53-67.

Structures and functional roles of the sugar chains of human erythropoietins.
Takeuchi M and Kobata A Glycobiology 1991; 1: 337-46.

The importance of N- and O-linked oligosaccharides for the biosynthesis and in vitro and in vivo biologic activities of erythropoietin. Wasley LC, Murtha TG, Stoudemire J, Dorner, AJ, Caro J, Dreiger M, and Kaufman RJ Blood 1991; 77: 2624-32.

Pharmacokinetics and administration of colony-stimulating factors. Petros WP Pharmacotherapy 1992; 12(2 Pt 2): 32S-38S.

Bioprocess factors affecting glycoprotein oligosaccharide structure. Goochee CF Dev Biol Stand 1992; 76: 95-104.

Enzyme-catalyzed oligosaccharide synthesis. Ichikawa Y, Look GC, and Wong CH Anal Biochem 1992; 202: 215-38.

Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis. Ichikawa Y, Wang R, and Wong CH Methods Enzymol 1994; 247: 107-27.

The effect of cell-culture conditions on the oligosaccharide structures of secreted glycoproteins. Andersen DC and Goochee CF Curr Opin Biotechnol 1994; 5:546-9.

Getting the glycosylation right: implications for the biotechnology industry.
Jenkins N, Parekh RB, and James DC Nature Biotech 1996; 14: 975-81.

Enzyme action in glycoprotein synthesis. Sears P and Wong CH Cell Mol Life Sci 1998; 54:223-52.

Cancer

Carbohydrate vaccines that induce antibodies against cancer. 2 Previous experience and future plans. Livingston PO and Ragupathi G Cancer Immunol Immunother 1997; 45: 10-19.

Cancer-associated glycosphingolipid antigens: their structure, organization, and function.
Hakomori S Acta Anat (Basel) 1998; 161: 79-90.

Ganglioside vaccines with emphasis on GM2. Livingston P Semin Oncol 1998; 25: 636-45.

The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy. Agrawal B, Gendler SJ, and Longenecker BM Mol Med Today 1998; 4: 397-403.

Evidence of a cellular immune response against sialyl-Tn in breast and ovarian cancer patients after high-dose chemotherapy, stem cell rescue, and immunization with Theratope STn-KLH cancer vaccine. Sandmaier BM, Oparin DV, Holmberg LA, Reddish MA, MacLean GD, and Longenecker BM J Immunother 1999; 22: 54-66.